Epidemiology of Diabetes Interventions and Complications Study (EDIC)
What Is EDIC?
The Epidemiology of Diabetes Interventions and Complications Study (EDIC) is an observational study examining the risk factors associated with the long-term complications of type 1 diabetes. The study began in 1994 and follows the 1441 participants previously enrolled in the Diabetes Control and Complications Trial (DCCT).
The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study is entering its 21st year. From 1983 to 1989, 1441 type 1 diabetic participants were recruited into the DCCT. They were randomly assigned to 2 treatment groups, intensive and conventional for an average of 6.5 years of randomized treatment time. The DCCT ended in 1993 after demonstrating conclusively that intensive treatment (mean HbA1c 7.2%) reduced the development and progression of diabetic retinopathy, nephropathy and neuropathy, compared to conventional treatment (mean HbA1c 9.0%).In 1994, 96% of the participants were enrolled in EDIC for regular observational follow-up of metabolic and complications status, using similar methods as in the DCCT. Diabetes care is obtained from the EDIC participants' own physicians.
The primary aim of EDIC is to examine the long-term effects of conventional vs. intensive diabetes treatment received during the DCCT on the subsequent development and progression of microvascular, neuropathic and cardiovascular complications. This involves studying the influence of genetic factors and other factors such as HbA1c, blood pressure, lipid levels, and treatment modalities on the development and progression of these complications.
EDIC Clinical Centers
EDIC is made up of 28 clinical centers and one data coordinating center funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
DATA COORDINATING CENTER
THE GEORGE WASHINGTON BIOSTATISTICS CENTER
CLINICAL COORDINATING CENTER
CASE WESTERN RESERVE UNIVERSITY